@article {573266,
	title = {Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.},
	journal = {Cell},
	volume = {84},
	number = {4},
	year = {1996},
	month = {1996 Feb 23},
	pages = {623-31},
	abstract = {Using a polymerization inhibition assay, we have purified a small, heat stable protein that physically interacts with tubulin dimers and increases the catastrophe rate of microtubules. Sequence analysis identified this protein as oncoprotein 18 (Op18)/stathmin, a conserved phosphoprotein that is highly expressed in leukemia cells. Immunodepletion experiments in Xenopus egg extracts showed that Op18/stathmin is involved in physiological regulation of mitotic microtubule dynamics. Op18/stathmin is a microtubule regulator that preferentially interacts with unpolymerized subunits. It is a candidate for increasing the microtubule catastrophe rate in mitosis and might also regulate microtubule dynamics in response to external signals.},
	keywords = {Animals, Cattle, Microtubule Proteins, Microtubules, Phosphoproteins, Stathmin, Thymus Gland, Tissue Extracts, Tubulin, Xenopus, Xenopus Proteins},
	issn = {0092-8674},
	author = {Belmont, L D and Mitchison, T. J.}
}
