@article {572991,
	title = {Phenotypic screening of small molecule libraries by high throughput cell imaging.},
	journal = {Comb Chem High Throughput Screen},
	volume = {6},
	number = {4},
	year = {2003},
	month = {2003 Jun},
	pages = {279-86},
	abstract = {We have developed high throughput fluorescence cell imaging methods to screen chemical libraries for compounds with effects on diverse aspects of cell physiology. We describe screens for compounds that arrest cells in mitosis, that block cell migration, and that block the secretory pathway. Each of these screens yielded specific inhibitors for research use, and the mitosis screen identified Eg5 as a potential target protein for cancer chemotherapy. Cell imaging provides a large amount of information from primary screening data that can be used to distinguish compounds with different effects on cells, and together with automated analysis, to quantitate compound effects.},
	keywords = {Animals, Combinatorial Chemistry Techniques, Eukaryotic Cells, Humans, Image Processing, Computer-Assisted, Microscopy, Fluorescence, Phenotype},
	issn = {1386-2073},
	author = {Yarrow, J C and Feng, Y and Perlman, Z. E. and Kirchhausen,T. and Mitchison, T. J.}
}
