@article {1345566,
	title = {A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine},
	journal = {Nat Commun},
	volume = {9},
	number = {1},
	year = {2018},
	month = {2018 08 06},
	pages = {3116},
	abstract = {Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFRα, and the analysis of GBM signaling pathways using proteomics. We discover the tubulin-binding protein Stathmin1 (STMN1) as a PDGFRα phospho-regulated target, and that this mis-regulation confers sensitivity to vinblastine (VB) cytotoxicity. Treatment of PDGFRα-positive mouse and a patient-derived xenograft (PDX) GBMs with VB in mice prolongs survival and is dependent on STMN1. Our work reveals a previously unconsidered link between PDGFRα activity and STMN1, and highlight an STMN1-dependent cytotoxic effect of VB in GBM.},
	keywords = {Animals, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Cell Cycle, Cell Survival, Cells, Cultured, Computational Biology, Disease Models, Animal, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Magnetic Resonance Imaging, Male, Mice, Neoplasm Transplantation, Phosphorylation, Proteomics, Receptor, Platelet-Derived Growth Factor beta, Signal Transduction, Stathmin, Vinblastine},
	issn = {2041-1723},
	doi = {10.1038/s41467-018-05036-4},
	author = {Jun, Hyun Jung and Appleman, Vicky A and Wu, Hua-Jun and Rose, Christopher M and Pineda, Javier J and Yeo, Alan T and Delcuze, Bethany and Lee, Charlotte and Gyuris, Aron and Haihao Zhu and Woolfenden, Steve and Bronisz, Agnieszka and Nakano, Ichiro and Chiocca, Ennio A and Bronson, Roderick T. and Ligon, Keith L and Sarkaria, Jann N and Gygi, Steve P and Michor, Franziska and Mitchison, Timothy J. and Charest, Al}
}
